L.B. Bohle Maschinen + Verfahren GmbH

Postfach 11 62, 59303 Ennigerloh
Industriestr. 18, 59320 Ennigerloh
Germany

Telephone +49 2524 9323-0
Fax +49 2524 9323-399
info@lbbohle.de

Hall map

interpack 2017 hall map (Hall 17): stand B43

Fairground map

interpack 2017 fairground map: Hall 17

Contact

Tobias Borgers

Phone
+49 2524 - 93 23 0

Email
t.borgers@lbbohle.de

Our range of products

Product categories

  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.01  Complete lines for the production of pharmaceutical and cosmetic products

Complete lines for the production of pharmaceutical and cosmetic products

  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.02  Single machines /equipment for the production of pharmaceutical and cosmetic products
  • 06.02.03  Coating systems for pharmaceutical and cosmetic products
  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.02  Single machines /equipment for the production of pharmaceutical and cosmetic products
  • 06.02.10  Fluid bed systems for pharmaceutical and cosmetic products

Fluid bed systems for pharmaceutical and cosmetic products

  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.02  Single machines /equipment for the production of pharmaceutical and cosmetic products
  • 06.02.11  Granulating machines for pharmaceutical and cosmetic products
  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.02  Single machines /equipment for the production of pharmaceutical and cosmetic products
  • 06.02.19  Mixers for pharmaceutical and cosmetic products
  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.02  Single machines /equipment for the production of pharmaceutical and cosmetic products
  • 06.02.20  Pharma extruders for pharmaceutical and cosmetic products

Pharma extruders for pharmaceutical and cosmetic products

  • 06  Machines and equipment for the production of pharmaceuticals and cosmetics
  • 06.03  Operating and auxiliary equipment for the production of pharmaceuticals and cosmetics
  • 06.03.09  Laboratory equipment - pharmacy and cosmetics

Our products

Product category: Coating systems for pharmaceutical and cosmetic products

BFC - High-End Bohle Coater for pharmaceutical applications

The high-end version of the Bohle coater designed specifically for high speed, problem-free coating, providing unparalleled tablet uniformity and efficiences. A high containment execution is also available.

Benefits of the Bohle Film Coater:
  • state of the art coating technology
  • homogeneous mixing due to patented spirals
  • gentle mechanial treatment of tablets cores to avoid edging and breaking
  • simple and quick discharging by reversing the direction of rotation
  • nozzles with AB-caps ensure long enduring operation
  • geometrical similarities of all machine sizes ensure secure scale-up conditions
  • unique cleaning abilities with integrated high-pressure washing-system
  • high sophisticated control system

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Product category: Granulating machines for pharmaceutical and cosmetic products

Fluid bed system Bohle Uni Cone BUC ®

Using a tangential fluid bed system represents state of the art technology in pharmaceutical manufacturing for particle coating, granulation and drying.

With the innovative and patented Bohle Uni Cone BUC® process a complete fluidization is assured which leads to a high coating uniformities and high yields in the final product due to the absence if particle twinning. Bohle Uni Cone BUC® is the productive, practical and precise alternative to conventional Wurster processing.

The BFS features a broad range of extension options for Bottom Tangential Spray Granulation as well as Bottom Tangential Spray Coating. All production systems are 12 bar shock pressure resistant.

A minimum of six seperately cleanable filter elements in the granulating system ensure that air flow through the product bed is not interrupted. The Bohle Fluid Bed System BFS is designed for through-the-wall installation.

The filter dome is attached to a frame in the engineering area.

The pivoting design of the product container with integrated inlet plenum is attached to the frame permitting easy access to the floor beneath the system. Two inflatable seals ensure air-tight sealing of the system.

The tangential base eliminates the need to remove the product container from the system to discharge it. The product is set in rotation by the tangential slotted openings in the base. A valve in the product container wall above tie base allows the content to be discharged directly. The centrifugal forces occurring during the product rotation ensure complete discharge.

The slotted base of the fluid bed system ascends conically towards the center, resulting in high stability of the base and process-related advantages through enhanced blending of the product. 

The discharge valve can also be used for vacuum assisted discharge of the product. The filter bag of each filter cartridge can be exchanged separately and easily. Furthermore the complete filter unit can be lowered for access from the floor level.

Benefits:

  • inline sieving and product transfer
  • 12 bar pressure shock resistant - optimum conditions for containment applications, no effect on environment in case of accident
  • integration of PAT, NIR and WIP
  • fliter cleaning by patent / patented diffuser
  • electrical drop down filter movement
  • filter cartridges with spindle drive
  • vacuum changing
  • removable bottom plate

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Product category: Granulating machines for pharmaceutical and cosmetic products

VMA - Single pot granulator for pharmaceutical applications

The VMA single pot granulator is a granulating and drying system specifically optimized for pharmaceutical applications. The Vagumator® single pot systmes are designed for closed, dust-free processing of pharmaceutical granules from charging through dicharge including in-line milling.

Mixing, granulation and drying cycles are completed in a single machine under contained conditions.

The impeller, with its high shear and compression, ensures effective granulation. The chopper prevents excessive granule growth and distributes the granulating liquid within the product.

The Vagumator® VMA offers optimal conditions for wet granulation of high-quality pharmaceutical products.

Ease-of-use and easy cleaning were key factors in the machine design. Large surfaces make for the machine’s easy cleaning. The top drive ensures that the seals of the impeller and chopper shafts are not exposed to the product, allowing for a longer service life. The centrally-positioned base outlet guarantees controlled product discharge and complete water discharge after cleaning.

The flexible machine is state-of-the-art, and exceeds current GMP requirements with regard to design, handling and control.

Benefits:

  • small footprint
  • easy through-the-wall-assembly
  • gravity feeding is standard
  • installation in hazardous areas
  • switch cabinet on board

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Product category: Mixers for pharmaceutical and cosmetic products

Blending systems for pharmaceutical applications

Bohle is the world’s leading manufacturer of blenders. The high efficiency of the Bohle blending systems is based on the revolutionary and patented counter-current process principle.

The range of Bohle blending systems shows the flexibility of our engineering and manufacturing departments. Bohle blenders can be adjusted and used in any imaginable pharmaceutical production situation.

No matter what kind of container you use, round and square, Bohle blenders can handle them with
excellent blending results.

Bohle provides blenders featuring a variety of different load bearing capacities:

  • standard arm connection and clamps
  • round forks on the lift arm
  • lift arm with eccentric, power and hydraulic clamps

The high efficiency of the Bohle blending systems is based on the revolutionary and patented counter-current process principle. There are numerous benefits: Effective blending volume of 20-85% of the rated volume.
The Bohle blending systems allow homogeneous blending of dry powder batches with its patented blending
elements mounted to the inside of the container lid. The blending procedure can be scaled up from
4 – 12,000 liters.

For full flexibility the blending containers can be exchanged to use different volumes if required. Due to the patented Bohle blending systems each blending container can be used for effective mixing between 20 – 85 %
of the total container volume for densities between 0.2 – 1.2 kg/l.

The Pharma Blender is a stationary blending device, consisting of:

  • PM machine body with load suspension device
  • electrical switch cabinet integrated in machine body.A separate installation is optional upon request
  • separate operator panel
  • safety light barrier or laser scanner as an option
  • The blending operation is a fully contained and closed process. Each container has an inner lid for filling procedures.

An extended hoist allows the blender to be also used as a milling station for bin to bin transfer.

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Product category: Complete lines for the production of pharmaceutical and cosmetic products

Compact granulation system: Bohle Compact Unit - Small footprint, high quality

The individual components of the High Shear Granulator GMA, wet sieve BTS, Fluid Bed System BFS and Bohle Uni Cone BUC®, cyclone separator and dry sieve BTS are optimally integrated into the Compact Unit. This integration covers process, cleaning, control and explosion protection as well as qualification.

The Compact Unit is a compelling solution when traditional wet granulation must be realized economically and ergonomically. Featuring many technological advances and inherent safety considerations, the Compact Unit creates an industry benchmark.

Small footprint, flexible application and smooth production processes are decisive criteria for investment in the pharmaceutical granulation system. In this respect, L.B. Bohle sets standards with the Compact Unit.

Benefits of the Compact Unit:

  • GMA Granulator® and Bohle fluid bed system BFS built into the wall right next to each other
  • small footprint and minimized room height
  • multipurpose use for various processes
  • single operator  panel to serve both machines
  • single WIP-skid to serve both machines
  • 12 bar pressure shock resistant design

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Product category: Coating systems for pharmaceutical and cosmetic products

Bohle Tablet Coater BTC. The economical choice for all coating applications

L.B. Bohle has developed the future of tablet coating, the high-efficiency Bohle Tablet Coater (BTC). The tablet coater reduces processing times up to 35 percent compared to conventional tablet coating systems, yielding significant cost savings and improved campaign efficiency while maintaining cGMP standards.

The Bohle Tablet Coater BTC provides superior coating uniformity, producing considerably fewer rejects and using less coating material. L.B. Bohle’s patented air flow bed technology eliminates spray drying, thereby reducing waste while lengthening campaigns between cleaning. It also promotes uniform tablet coating with a high-quality, defect-free film coat.

The tablet coater’s elongated coating pan provides a larger tablet spraying surface accommodating up to 10 spray nozzles, which delivers more suspension solution and reduces overall coating time. The Bohle Tablet Coater BTC’s integrated mixing baffles are double-helix shaped to ensure thorough tablet mixing with gentle handling. The baffle design provides 100-percent tablet discharge, increasing campaign efficiency.

The Bohle Tablet Coater BTC is the most economical alternative for all common coating applications.

The benefits of the Bohle Tablet Coater BTC:

  • state of the art coating technology
  • homogeneous mixing due to patented spirals
  • gentle mechanical treatment of tablet cores to avoid edging and breaking
  • simple and quick discharging by reversing the direction of rotation
  • nozzles with AB-caps ensure long enduring operation
  • minimizing loss of spraying solution to to a value below 5 %
  • geometrical similarities of all machine sizes ensure secure scale-up conditions
  • friendly operator software and visualization

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Product category: Granulating machines for pharmaceutical and cosmetic products

Compactor BRC 25 and BRC 100 - Economical dry granulation

In the dry granulator powders are processed into fluid granules. The objective in the pharmaceutical industry is to process a granule with defined density or porosity for immediate tabeletting thereafter. The powder is fed via a dosing unit, compacted between two rollers with gaps ranging from 1 to 6 mm and discharged as scabs.

The impact on the rollers, as well as the gap width are monitored sensorially and integrated into a control circuit to ensure continuous optimum process parameters. The chopper unit below the compact rollers processes scabs into granules. The unit is equipped with a conical sieve with exchangeable sieve units for processing different particle sizes. Especially the control of the pressing force via standard hydraulic systems constitutes a great problem, when the process is aimed to comply with “hygienic design”. With the innovative electro-mechanical batch L.B. Bohle is able to solve this problem.

With the Bohle BRC dry granulator, frequent axis adjustment as with traditional roller compactors is a thing of the past. Thanks to a special bearing method, the axes are mechanically stable so that elastic deformation is prevented. This eliminates the need for complete axes control!

Moreover, the dry granulator BRC is low maintenance. Even when cleaning is required, only four screws must be removed. Furthermore, Bohle engineers reduced the overall height by 20 percent.

Bohle is now able to offer the customers machines and processes for all stages of the granulation process with the new BRC – continuously, and with the proven Bohle quality.


  • The advantages of the new Bohle - BRC dry granulator:

  • Minimal material loss due to precise control of the compression force with an innovative electromechanical roller drive
  • Constant ribbon properties assured with sensitive gap width control
  • Easy handling and short mounting procedures
  • Hygienic design and effective cleaning by integrated WIP nozzles
  • Versatile and gentle particle size adjustment with integrated Bohle Turbo Sieve (BTS 200)
  • PAT tool integration possible

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Product category: Granulating machines for pharmaceutical and cosmetic products

Bohle continuous granulator BCG

Advantages of the BCG:

  •  Pharma-compliant design
  •  Truly continuous process
  •  Flexible screw layout – adapting to customer process
  •  Independent torque measurements for both screws
  •  Integrated thermal control for screw housing
  •  Designed for blending and wet granulation

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Product category: Complete lines for the production of pharmaceutical and cosmetic products

Continuous processing unit

The continuous production line is a modular solution. In contrast to existing systems, the modular system allows the flexible arrangement of different unit operations, opening the path for a specialized solution depending on the requirements of the customer.

The continuous production line provides a nominal output range of approx. 5 to 25 kg/h. The production line is designed as a flexible layout concept, allowing exchanging or removing single unit operations. In this way the three most commonly production layouts direct compression, wet granulation and dry granulation can be realized

The inclusion of dry compaction in a continuous working process is unique and it is much more economic and less energy intensive in contrast to the wet granulation process. By the integrated analytics the interim storage and the laboratory analytics will mostly become obsolete. The costs for storage room and stored material will be extremely reduced. The manufacturing process will be also reduced, allowing higher production capacities and faster response to short-term demands. With the continuous processes the scale up of the production output is achieved by extending the production time, rather than by batch sizes.

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Product category: Coating systems for pharmaceutical and cosmetic products

ROB 50 optimizes production processes in continuous and batch-oriented processing

L.B. Bohle presented the ROB 50 as innovative solution to automate and optimize production processes in both continuous and batch-oriented production of solid dosage forms.
The ROB 50 is a robotic system for handling of tablet containers, to close the gap between the tablet press and film coating process.

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Product category: Coating systems for pharmaceutical and cosmetic products, Laboratory equipment - pharmacy and cosmetics

Bohle Film Coater BFC 5 - Laboratory Coater

The Bohle Film Coater BFC 5 is a stand-alone unit. The entire air technique as well as electrical and control technique is integrated in the system.

Multipanel visualization with touch panel, operator unit is attached to coater. An electrical connection and a compressed air connection are required for operation.

The pan can be dismantled, which results in easy cleaning. Furthermore, a larger pan can be optionally installed. The Coater BFC 5 can be operated with two pans, whereby the smaller pan can be separated with cutting disc.

The Bohle Film Coater BFC 5 is suitable for batch sizes of 2 to 13 liters. A transport trolley is supplied for easy discharge and for pan transport.

  • Benefits of the Bohle Film Coater BFC 5:

BFC 5 can be operated with one of two differtent pan sizes. Coater pans are changed manually
the capacity of the smaller pan can be reduced with a divider plate
batch sizes from 2 to 13 liters
computerized Win CC visualization with extensive batch management tools and broad range of tools for preparing recipes
multipanel visualization with touch panel, operator panel is attached to the coater
manual cleaning

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Product category: Coating systems for pharmaceutical and cosmetic products

Bohle Film Coater BFC TriPan - with three exchangeable pans

The BFC TriPan Film Coater is designed specifically for high speed, problem free coating, providing unparalleled tablet uniformity and efficiencies. TriPan is a Bohle Film Coater with a suspension supply  via a single pump head.

TriPan can be operated with three pans for batch sizes of 7 to 75 liters.
TriPan can be operated with three pans for batch sizes of 7 to 75 liters. Change of pans using a lifting device. Computer-supported InTouch visualization with extensive batch management tools and a broad range of tools for preparing recipes. Easy cleaning of the BFC TriPan thanks to high pressure cleaning of the pan inside.

Benefits of the Bohle Film Coater BFC TriPan:

  • batch sizes from 7 to 75 liters
  • computerized InTouch visualization with extensive batch management tools and a broad range of tools for preparing recipes
  • easy cleaning thanks to a high pressure system on the inside of the pan
  • suspension supply via a single punp head

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Product category: Mixers for pharmaceutical and cosmetic products, Laboratory equipment - pharmacy and cosmetics

LM 40 - Laboratory blender for pharmaceutical apllications

The Bohle Laboratory Blender LM 40 is a mobile unit. The blender itself is integrated into a frame with lock casters. A plexiglas cover protects the type MC blending containers (standard container sizes: 5, 10, 20 and 40 litres) during rotation to ensure full worker safety.
The Bohle blending technology has been demonstrated to be fully scalable from five liters (LM 40, as presented) up to 12,000 liter blenders.
The cover is opened to allow access to the MC blending container. If the cover is opened during blending, a safety switch will stop the unit. The blender has a drive unit with a bevel gear motor and a potentiometer control to infinitely adjust the rotational speed.
The Bohle blending system provides the maximum in blending performance, precision and accuracy. A laboratory scale blender is available for trials in our Service Center in Ennigerloh, Germany.

The advantages of the LM 40:
  •  mobile unit
  •  results fully scalable from 5 up to 12,000 liters
  •  integrated safety switch
  •  operator-friendly, modular and compact design
  •  easy, fast and complete discharge

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Company news

Date

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Apr 28, 2017

Cooperation L.B. Bohle and Korsch AG

L.B. Bohle and KORSCH – two specialists jointly represented at Interpack 2017
Numerous machine highlights at the leading trade fair

Ennigerloh/Düsseldorf, May 2017 – L.B. Bohle Maschinen + Verfahren GmbH, the global technology and market leader for process machines in the pharmaceutical industry and KORSCH AG, a globally operating specialist for tablet press technology, will present their products together for the first time at Interpack 2017 in Düsseldorf. Both companies offer highly innovative technologies that complement each other. The partners have already proven this in numerous projects which required integrated solutions and processes.

Product ranges complement each other perfectly

"Our cooperation was once again intensified through the development of the continuous production plant at our Technology Center. The experience made us realize that we can support each other on many levels,” says company founder Lorenz Bohle. Stephan Mies, Chairman of the Management Board of KORSCH AG, adds: “Our product ranges complement each other perfectly. Together we can plan, design and implement the entire production process of our customers. It was therefore only logical to use Interpack 2017 as a common platform.”

Both companies offer technical innovations and services, and work on projects on equal footing as partners, without jeopardizing the independence and autonomy of their companies.

By the joint trade-fair appearance, L.B. Bohle and KORSCH provide their customers with detailed information on individual technologies as well as strategies and projects for the implementation of complete production lines and processes – both for batch and continuous production solutions.

We look forward to your visit in Hall 17 - Booth B 43/ B51

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Apr 28, 2017

Tablet checker KA 280 Update for the bestseller in worldwide demand

For more than 30 years, pharmaceutical manufacturers worldwide have been using the KA tablet checkers by L.B. Bohle. At Interpack 2017, the specialist machine builder from Ennigerloh will be presenting the KA 280, the latest generation of effective tablet sorting machines.

The thickness of sugar coated tablets and film tablets is one of the most important criteria in the production of pharmaceutical solids: Nuances decide whether a tablet has been produced with the correct dimensions and can thus be further processed or whether it has to be disposed of. The control of such subtle differences presents both organizational and economic challenges for the producers – after all, each tablet must be inspected. For more than three decades, L.B. Bohle has offered the tablet checker KA. The latest KA 280 version has been further refined in terms of precision and throughput: up to one million tablets can be checked by the device per hour.

Precise and low-maintenance

These tablets are filled into the hopper. A vibration system transports the tablets to the rotating sorting discs arranged in pairs. Here, the tablets are divided into three different groups: Too thick tablets are placed in a tray above the dispensing tray Tablets that are too thin are discarded on a tray below the dispensing tray in the middle. Tablets of the correct size are fed to the production area. Employees can control the entire process via a touch panel (HMI) and change the settings for thickness measurement, for instance. The lowest measurable deviation is ± 0.1 mm.
In the design of the new KA 280, the Bohle developers focused on ergonomic and simple handling with  low-maintenance.


 

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Apr 28, 2017

Bohle BRC 25 - Small dry granulator rounds off the range of products

Ennigerloh/Düsseldorf, May 2017 - With the Bohle BRC 25 dry granulator, L. B. Bohle presents a compact version of the BRC 100, which has been in operation since 2012, at Interpack 2017. The BRC 25 is designed for simple handling, continuous production and a small footprint.

Roller compactors such as the BRC 25 are used for processing powder into free-flowing granulates. For pharmaceutical manufacturers, it is crucial to obtain a granule with a precisely defined thickness and porosity for immediate tabletting in the following step. To this end, the powder is fed via a dosing unit, compacted between two rollers with gaps ranging from one to six mm and discharged as slugs. This is a compacted, band-shaped material. The thickness of the slugs depends on the press force of the rollers and the gap width. These parameters are defined in advance and monitored by sensors. All data are integrated into a control circuit to continuously ensure optimum process parameters.

The chopper unit below the compact rollers processes slugs into granulates. The unit is equipped with a conical sieve with exchangeable sieve units to achieve different particle sizes.

Innovative roller control

In conventional hydraulic systems, it is particularly problematic to control the press force of the rollers if the process must be in accordance with hygienic design, i.e. the design of components which is suitable for cleaning. For example, a hydraulic system only works with appropriate lubricants, which pollute the environment and pose a risk of contamination. The BRC 25 is therefore based on the proven electro-mechanical design of the BRC 100, since it is particularly easy to configure and clean.

With the Bohle BRC 25, the need for frequent adjustment of the axes, as necessary with conventional roller compactors, is also eliminated. The axes are mechanically stable so that elastic deformation is prevented. In addition to high reliability, this ensures uncomplicated maintenance: Even if cleaning is required, only four screws must be loosened. Furthermore, Bohle engineers reduced the overall footprint by 20 percent. Nevertheless, users of the BRC 25 can switch to the larger model at any time: Roller geometry and control are identical in both machines.

 


 

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Apr 28, 2017

Bohle Film Coater BFC: Technological edge for pharmaceutical film coat-ing

Ennigerloh / Düsseldorf, May 2017 - Tablet coating is becoming increasingly popular as a carrier of active ingredients in the pharmaceutical industry. This is a logical result of the ever-improving production processes that have been developed by special machine builders such as L.B. Bohle for years. At Interpack 2017, a bestseller takes center stage with the Bohle Film Coater BFC. The BFC enables active ingredient coating with highest precision. An alternative drum makes the coater particularly flexible. Thus, especially small tablets can be coated as well.

The significance of coating technologies has continued to increase in recent years. Tablets are mainly coated to control the release of active ingredients, protect the active ingredient against light and moisture or cover the bitter flavor. Especially the so-called active ingredient coating – i.e. the processing of active ingredients for tablet coating – is becoming increasingly important. Both versions can also be used in one product: Modern formulations often comprise several methods of active ingredient coating. This leads to long process times and an increased demand in machines which handle the complex tasks as automatically as possible. In this area, L.B. Bohle Maschinen + Verfahren GmbH, based in Ennigerloh (Westphalia), has established itself as a market leader with its film coaters.

Coating uniformity is a crucial factor for the production of coated tablets. This means that all tablets must be coated in exactly the same way. Bohle coaters like the BFC and the BTC achieve a standard deviation of less than two percent. This is unmatched in the market.

BFC as technology leader

The coaters owe their high reliability to their design: The flat tablet bed in a long drum geometry as well as continuous adjustment of the inclination angle ensure optimal movement of the cores. Thanks to the systematic forced guidance in the drum of the BFC, the product is in constant movement. This prevents the formation of twins, i.e. tablets that stick together and are unusable.

Furthermore, the inclination angle of the housing can be adjusted and cleaned with high pressure and is suitable for so-called high-containment applications thanks to inflatable seals on the inspection doors. Each nozzle is also equipped with a pump head which constantly measures the pressure so that blocked nozzles can be identified immediately. The Bohle Coaters of the latest generation can be operated via the visualized "InTouch” user interface, which offers extensive batch management functions and a wide range of functions for recipe creation.

More flexibility by customer request

In 2009 a slotted coater drum was developed as part of a customer project. One customer needed a coater to be able to coat miniature pellets with a diameter of less than three millimeters – a requirement that cannot be met by a system with standard perforation. Miniature tablets have been a common dosage form for some years now. They are especially suited for use of multi-particle dosage forms as they can be individually and flexibly dosed. To this end, they can either be filled into capsules or sachets or applied with miniature tablet dispensers. However, the small cores must be sufficiently stable, which is why they are often coated. Besides functionality, swallowing as well as taste and odor are positively influenced by the film coverings.

But the miniature tablets are often very fragile and may abrade or break due to strong fluidization required in the fluidized bed. Therefore, L.B. Bohle designed a slotted coater drum for moregentle handling of the small cores in 2009. This drum was designed with a corresponding perforation in which not only standard but also extremely small cores with a diameter of 1.5 millimeters can be coated. This gives the system maximum flexibility and enables processing of different particles.


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Apr 28, 2017

Continuous Granulator - BCG 25 Twin-screw extruder: Flexibility is key

Ennigerloh / Düsseldorf, May 2017 - Versatility and accuracy are a must in the production of granulates: The smallest deviations in grain size determine the production success. With the BCG, L.B. Bohle presents a flexible twin-screw extruder at Interpack, which can be used separately or as part of a production line.

The powdery base material is fed and moistened via gravimetric feeders, which analyze the mass of the powder. This produces coarse granulates, which are further compressed and mixed in the BCG by a twin-screw. The screws can be designed flexibly. Granulates of different porosity can thus be produced, which meet all requirements for subsequent drying and tabletting.

The control concept is linked to Process Analytical Technology (PAT), which enables standardized controls of processes and materials. This leads to consistently high product quality with very low deviations because the process is automatically controlled by PAT and precisely pre-defined properties. In addition, NIR spectroscopy is integrated into the system for molecular analysis of the granules. The BCG allows for higher production rates and, at the same time, less waste material compared to conventional granulators. This benefits customers, as operating costs are significantly reduced.

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Apr 28, 2017

Solid growth also in 2017: Trade fair appearance and cooperation provide further impetus

Ennigerloh/Düsseldorf, May 2017 – L.B. Bohle has increased its profit in 2016 to approx. EUR 50 million. “We had a very good year with sustained high demand in Germany,” reports Managing Director Tim Remmert at the kick-off to Interpack in Düsseldorf. Moreover, major projects in Switzerland, Russia and Latin America as well as a stable development in the US contributed to this success. “For 2017, we expect solid growth,” states Remmert. “The trade fair appearance and the cooperation with Korsch AG are to provide further impetus.”

No less than eight coating machines were installed by L.B. Bohle in 2016 in Germany alone. “Most customers are already working with Bohle coaters and have put their trust in the proven technology when an extension or replacement was necessary,” reports Managing Director Tim Remmert. International customers increasingly request containment solutions in which highly-active substances are securely processed in contained systems. Remmert: “The Russian market, for instance, continues to offer high growth potential as the government drives forward the development of a local pharmaceutical industry.” In the US a key project could be implemented for one of the major pharmaceutical companies with a fluid bed granulation system in 2016. These references have potential as “the high requirements placed on automation” have to be satisfied.

More than 20 BRC systems sold

The dry granulator BRC has meanwhile also turned out to be very promising. “The first BRC already premiered at ACHEMA 2012,” the Managing Director, Thorsten Wesselmann, recalls. After experiencing positive customer reviews and building references, more than20 systems from the BRC series were sold in the past 2 1/2 years alone.

References built up in India

When it comes to sales, the Bohle Management not only relies on the established Western European countries but also Asia and Latin America. “In India we have installed the first large plants with coaters and blending technology,” reports Tim Remmert. Follow-up orders in this growing pharmaceutical market are in the focus of our marketing strategies. The Chinese market is a more difficult environment. There L.B. Bohle is primarily assigned with the installation of new production plants for renowned Western manufacturers. In South America the reinforced sales team profits from the booming economy in Chile and Argentina. “In Brazil, on the other hand, the economic crisis also affects the pharmaceutical industry.

Major contract won in Algeria

Positive impetus comes from North Africa. The company had already achieved sales success in the Maghreb states in previous years. Head of Sales Tim Remmert: “We won a major contract in Algeria in 2016, the processing of which will keep us busy in 2017.”

More and more customers use Technology Center

In light of the Interpack trade fair, Management expects continued “solid growth” for the business year 2017. The objective is to exceed the strong performance of 2016. Continuous production plays a key role in this context. "We constantly receive visits from customers who are developing individual solutions for continuous processes together with our experts in the Technology Center," explains Thorsten Wesselmann. The customers are "thrilled" by the possibilities in the Technology Center and the engineering know-how. These projects are "complex in every respect". It is therefore difficult to assess when investment decisions will be made. "When decisions are finally made, we expect higher sales growth. A continuous system alone is worth between EUR 6 and EUR 20 million,” the Managing Director predicts.

Flexibility as competitive edge

Company founder Lorenz Bohle supports the ambitious goals as Chairman of the Advisory Board. He sees potential in the even closer cooperation with Korsch AG. "We are two of the few independent medium-sized companies that can technologically compete with the large corporations," explains Bohle. At the same time, both companies are extremely customer-oriented. Bohle: "Short decision-making processes and financial independence enable us to implement new developments faster and more flexibly than our competitors.”

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Apr 28, 2017

L.B. Bohle highlights clear goals at Interpack

New Managing Directors Tim Remmert and Thorsten Wesselmann stand for continuity

Ennigerloh/Düsseldorf, Mai 2017 – In their role as new Managing Directors of L.B. Bohle Maschinen + Verfahren GmbH, Tim Remmert and Thorsten Wesselmann will introduce themselves as the new management duo at the Interpack trade fair. The former Head of Sales and Head of Technology are well-known members of the management board of the Westphalian specialist machine builder. “We stand for continuity,” states Tim Remmert.  The joint trade fair appearance with the specialist for tablet presses – the Berlin-based Korsch AG – demonstrates further development projects and a workshop on continuous production in the autumn of 2017.  These steps mark a clear vision for the future of L.B. Bohle.

At first glance, L.B. Bohle Maschinen + Verfahren has gone through major changes in the previous six months: Two new managing directors have taken over operational responsibility from the company founder Lorenz Bohle, who joined the Advisory Board. An even closer cooperation with Korsch AG will be announced at the Interpack trade fair with a joint booth as a sign of comprehensive solution expertise. At the same time, continuous production is being pushed ahead with numerous customer tests at the Technology Center in Ennigerloh. Solid particle production in the pharmaceutical industry is going to reach new dimensions.

“All the changes that can be seen now are the result of consistent, long-term development and do by no means represent an abandonment of our previous strategy,” Managing Director Tim Remmert and the owner Lorenz Bohle declare in unison. “We are taking the next important steps,” states Lorenz Bohle. He regards the successful generation change as well as the on-going development of continuous processes as a good basis for a medium-sized machine building company to compete with global companies in the future.

Workshop at the Technology Center in September

“Through the cooperation with Korsch and Gericke as well as with the universities HHU Düsseldorf, RWTH Aachen and the Rutgers University in New Jersey, L.B. Bohle has prepared the ground for meeting the high requirements of automation,” explains Tim Remmert. The modular combination of individual systems and the integration of cutting-edge measurement and analysis technologies offer optimized solutions for the individual requirements of the pharmaceutical solid dosage industry.

Customers can obtain information on the status of continuous production and its benefits at Interpack in hall 17, booth B 43 and B 51. From 19-21 September 2017, L.B. Bohle has organized an international workshop on the development of continuous productions in pharmaceutical production at the Technology Center in Ennigerloh.

To register and for more information, please visit
www.continuous-production.com

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Apr 20, 2017

Bohle Coating Technology

Pharmaceutical film coating represents nowadays an important process step in the pharmaceutical industry. Derived originally from dragee pan processing, coating technology has developed continuously in the last decades. The majority of coating processes are performed for drug release
modification, drug stability improvement against light or moisture and taste masking. Furthermore patient compliance issues play an important role, as swallowability improvement or a simpler identification due to a different colour.

Finally API coating is gaining more and more importance since it enables fixed dose combinations or the combination of incompatible drugs. Also different drug release characteristics can be realized by applying for example sustained release coatings in addition to immediate release coating layers. Such formulations sometimes consist of up to four coating layers, which leads to long processing times. To successfully develop and produce such formulations coating uniformity is a prerequisite and a quality attribute, since coated tablets have to pass the test on uniformity of dosage units according to the pharmacopoeias [1, 2]. As a coating process consists of simultaneous spraying, mixing and drying processes, a good coating uniformity can only be achieved with the choice of the proper parameters. To meet these requirements L.B. Bohle developed and improved its coater design in the last years.

The Bohle Coating Technology contains three unique design principles which assure a good coating uniformity:
Bohle pan geometry with an L/D ratio >1 offers a large tablet bed surface, which allows the incorporation of a high number of spray guns. Compared to conventional pan geometries that can be found in the market, process time can be saved up to 40% due to larger throughput
of coating suspension. Besides the thinner tablet bed induces a minimum shear onto the tablets, which allows even the coating of very weak tablets.

The unique helical baffles (patented) consist of two layers of baffles . They are responsible for the continuous and homogeneous axial mixing within the tablet bed. In addition the drum rotation is maintaining the radial mixing. Both movements are a guarantee for a dead zone free tablet bed.
Thus a homogeneous mixture in the tablet bed is usually achieved within a few minutes. Due to the constant tablet movement the tablets do not experience any acceleration peaks which could cause tablet damage or even twinning.

The air principle in Bohle Film Coaters utilizes the drying capacity where it is most needed: in the tablet bed (Fig. 3). Thus most effectively the drying capacity of the inlet air is used without heating the rest of the coater inner parts. The inlet air is coming from below the tablet bed and is directly sucked through the rotating tablet bed into the exhaust air funnel. This setup offers also another advantage: The spray guns are not being heated during coating and remain cool. Therefore spray losses are reduced to a minimum which leads to coating efficiencies of >95% which is especially beneficial for API coating processes.

 Besides these unique features making the Bohle Coating Technology so successful, these coating machines can be equipped with CIP systems. At high pressure values the cleaning takes place with a cleaning lance which effectively cleans the coater after production in an automated mode.

The Bohle coating equipment is available form lab scale to large production scale.

Furthermore different configuration lines are available meeting different customer needs on all continents. Besides the classical batch mode machine types, semi continuous coaters are also available.

References
[1] European Pharmacopoeia, Monograph 2.9.40. Uniformity of dosage units, 7th ed., Directorate for the Quality of Medicines of the Council of Europe, Strasbourg, 2011.
[2] United States Pharmacopoeia, Monograph <905> Uniformity of Dosage Units, 35th ed., U. S. Pharmacopoeial Convention, Rockville, 2011
[3] Optimization of inter-tablet coating uniformity in an active coating process, Just S. et al., Poster presentation AAPS Annual Meeting, Chicago 2012

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Apr 20, 2017

Bohle Blending Systems - An integral element to the L.B. Bohle success story for almost 30 years

The company’s history began with a blender in 1987 – in the meantime, L.B. Bohle, the machine builder from Ennigerloh, has manufactured more than 3,000 blenders. Day by day, the most varied blending systems are used in the production lines of pharmaceutical companies and toll manufacturers worldwide.

Thanks to the innovative design, flexibility and a long service life of the machines, L.B. Bohle has become the world market leader in the area of blenders.

Five different pick-up systems
The product portfolio is distinguished by a great variety thanks to high flexibility in the areas of construction and production. In this way, the blenders can be adapted to the customer’s individual production requirements and daily specifications. The blenders of L.B. Bohle are used in all conceivable production scenarios in pharmaceutical production.

Thanks to the patented blending elements installed on the inside of the container lid, all blending systems allow for very homogeneous blending of the powder batch. Depending on the process, scaling is possible from 14 to 12,000 litres. As standard, the blending containers come as interchangeable containers with a volume of up to 2,400 liters. Due to the patented Bohle blending systems, each blending container can be used for effective mixing between 20 and 85 percent of the total container volume for densities between 0.2 – 1.2 kg/dm³. Another important design feature is different pick-up   systems. L.B. Bohle offers its customers five different pick-up systems.

Electronically monitored quick clamps
Versions with standard load arm and clamps are most frequently requested. The containers are docked via four electronically monitored quick clamps. Containers with a volume of up to 1,200 liters, which are mounted on an undercarriage, can be adapted to the blender without additional lifting equipment being required. Optionally, a chopper installed in the container lid can be used. The drive of this chopper is integrated into the load arm of the blender.

Thanks to the extreme high flexibility of the blender design, there is also a version in which the system can be swivelled around its vertical axis. This allows for optimum adaptation to the customer’s requirements. Further advantages of the design include the long service life and extremely low maintenance requirements.

In another much sought-after version of the pharmaceutical blender, the container is slid onto two pick-up mandrels with its adapter pipes. Two screws on the front side grip the container and prevent sliding. As with other Bohle blending systems, the container is lifted through the blending systems and set into rotation.

Ideal solution for automated container pick-up
In the third version of our blending systems, the load arm is equipped with eccentric clamps. The containers are picked up with tines and braced automatically through eccentric movement in the pick-up pipes, the so-called adapter pipes. This is a very safe pick-up method which is ideally suited for automated container pick-up, for instance on a guide rail. If the containers are equipped with a circumferential frame, they can also be picked up and set down in inverted position. This model is also available as a pivoting version which can be swivelled around the vertical axis. Another version is equipped with a load support with power clamps. These apply pressure on the lower frame of the standing frame, ensuring that the container is tightly braced with the load support.

They can either be adapted via the standing frame or through support rails at the machine body. Load handling is possible either straight or at an angle of up to 30 degrees to take into account existing blending processes. This system has proven itself in its many years of use in the SFM type Bohle blenders.

As a fifth version, L.B. Bohle offers a system in which the load arm is equipped with hydraulic clamps. The containers are clamped hydraulically between the fixed and the movable part of the load support. Various sensors with the corresponding control ensure safe operation of the system. Load handling can be adapted to different container types. Pick-up at an angle of 30 degrees is possible as well. In connection with a lifting unit, the design is especially flexible and, above all, has a small footprint.

All these five versions of mixing systems by L.B. Bohle demonstrate the flexibility of the design, irrespective of the container type used in production: Bohle blenders can handle round or square containers with excellent blending results.

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Apr 20, 2017

ROB 50 optimizes production processes in continuous and batch-oriented processing

Closing the gap between tablet press and filmcoating 

In 2015 L.B. Bohle presented the ROB 50 as innovative solution to automate and optimize production processes in both continuous and batch-oriented production of solid dosage forms. The ROB 50 is a robotic system for handling of tablet containers, to close the gap between the tablet press and film coating process.

As indicated initially, L.B. Bohle developed this system for the continuous production line. However, the ROB 50 can also automate the product transfers in batch environment, to close the gap between tablet press and film coater. In this case, the ROB 50 is also available for larger container sizes. In addition, in case of long process times for the film coating process, the ROB 50 can server to coaters positioned next to each other in an alternating manner. Customized versions with an additional degree of freedom are available, too. For higher throughput or long relaxation times, L.B. Bohle also have solutions to automate the storage rack.

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Apr 20, 2017

Three-in-one: VMA 600 Ex CIP single pot granulator

For decades, high shear single pot granulation has been a well-established process technology within
the pharmaceutical industry. This process combines three process steps in one pot

1. blending,
2. high shear wet-granulation and
3. drying (under vacuum, gas stripping and/or microwave heat).

The single pot granulator offers many advantages for pharmaceutical companies:
  • Safe production in a closed container under vacuum
  • High blending and granulation efficiency, even with low dosage API (<1 %)
  • Low drying temperatures under vacuum, especially suited for temperature-sensitive products
  • Small product contact surface for quick and easy cleaning and fast product change-over
  • Efficient solvent recovery through cooling water
  • Small footprint
The Bohle VMA series includes typical pharmaceutical single pot granulators with impeller and chopper unit and top drive for pharmaceutical applications.

Two agitators provide the necessary shear forces and de-lumping to achieve high-quality granulates.

The heart of the machine is the GMPcompliant double jacket process bowl. The main aggregates are integrated in the lid of the pot (“top drive”). It contains the impeller shaft and sealing, the chopper shaft and sealing, the product filter, the microwave window, the temperature and pressure sensors as well as the retractable cleaning nozzles.

 The granulation process is automated/plc-controlled. The product-specific recipes are simply loaded from a PC and the required process functions can be set via HMI:

FEEDING:
The raw powder is fed by vacuum first, e.g. from an IBC container.

BLENDING:
The powder is blended through the main impeller for a few minutes.

GRANULATION:
The binding agent is added to the product from a stirred liquid tank via mass flow sensor and peristaltic pump to an atomizing spray nozzle. At the same time, the impeller and chopper provide the necessary shear forces to generate granules.

WET MIXING:
If required, a short wet mixing phase can be integrated into the process after adding the liquid to bring the granules to the final size and shape.

VACUUM DRYING:
Three different vacuum processes are available for drying the granules down to the desired moisture content:

1. pure vacuum drying,
2. vacuum drying with strip gas (VAGAS®) or
3. with vacuum microwave drying. The organic solvent vapors are condensed and can be recovered or discharged in an especially effective and environmentally safe way.

 DISCHARGING:
The process bowl can be easily discharged through the center discharge valve via an inline conical turbo sieve (Bohle Turbo Sieve BTS 200) into an IBC container.

CLEANING:
Before processing another product, the unit should be cleaned. The cleaning process of the VMA is automated, recipe-controlled and very quick. A CIP rack in the technical area provides the cleaning water at the required temperature, amount and detergent concentration.

When drying is performed, the evaporated solvents are discharged from the process bowl to the vacuum system.

For environmental reasons, the organic solvent vapors containing e.g. acetone or ethanol are easily and very efficiently condensed in tube condensers.

The required cooling water is held steady at -30 °C or -20 °C or +5 °C in a chiller unit (see picture).

The emission rate of e.g. acetone or ethanol can be set to below 20 % LEL (lower explosion limit).

 The “compact all-rounder” is offered at capacities between VMA 70 to VMA 1200 which corresponds to batch sizes of 20 – 960 litres.

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Apr 20, 2017

BRC – Compactor for Pharmaceutical Production

Homogeneous Granulates in a Continuous Process Thanks to Dry Granulation

Continuous processes with dry granulation
Dry granulation often is the process of choice for high-volume or moisture-sensitive products. The BRC Granulator by Bohle is suited for continuous production and offers the possibility of integrating Process Analytical Technology (PAT).

The benefits of the BRC 25 and BRC 100 Dry Granulators:
  • Minimum material loss due to precise pressing force control by means of electromechanical roller drive
  • Constant scabbing characteristics thanks to efficient gap control at high material throughput
  • Easy handling and short set-up times
  • Hygienic design with integrated washing nozzles for WIP (Washing in Place) processes
  • Flexible and careful granulation with integrated Bohle Turbo Sieve (BTS)
  • PAT integration possible
  • Free-flowing granulates with homogeneous distribution of active ingredients
The benefits in detail:
In the roller compactor, powder is processed to free-flowing granulates. In contrast to classic wet granulation, no energy-intensive drying processes are needed here; this avoids high investments in systems and production rooms, resulting in lower costs per batch.

The aim of pharmaceutical production is a homogeneous distribution of all powder ingredients to prevent separation of the individual components. At the same time, the granulates must attain a defined density or porosity. These are important characteristics which have a decisive impact on the dosing accuracy of the granulates.

The powder is compacted between two rollers with gaps ranging from 1 to 6mm and discharged as scabs. The impact on the rollers, as well as the gap width are monitored sensorially and integrated into a control circuit to ensure optimum process parameters at all times.

The granulator unit below the compacting rollers processes the so-called scabs into smaller granular particles. The integrated turbo sieve (Bohle Turbo Sieve BTS 200) granulates the scabs gently even at high throughputs and can be variably designed with different sieve inserts for various particle sizes. In addition to the Bohle Turbo Sieve, integration of the Bohle Rotation Sieve (BRS) is possible as well.

Electro-mechanical dry granulators with variable gap
Especially the control of the pressing force via standard hydraulic systems constitutes a great problem, when the process is to comply with “hygienic design”. The innovative electro-mechanical approach of L.B. Bohle solves this problem. With the Bohle BRC, frequent axis adjustment as with traditional roller compactors is a thing of the past. The axes are mechanically stable so that elastic deformation is excluded. This eliminates the need for axis control! Moreover, the BRC is low maintenance. Even when cleaning is required, only four screws must be removed. With the compactors of the BRC series, L.B. Bohle offers its customers machines and processes for all stages of the granulation process – consistently in the proven Bohle quality.

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Apr 20, 2017

L.B. Bohle Receives Ex-Certification

Acceptance of the quality assurance and production process


The European Union published the so-called ATEX guidelines for the first time in 1994. In 2014 a new version of the directive was issued.
Directive 2014/34/EU covers equipment and protective systems used in potentially explosive atmospheres. This also applies to the sieving
machines of the BTS 100 and BTS 200 series of the Ennigerloh-based machine builder, L.B. Bohle.

“In order to provide our customers with the highest degree of safety, L.B. Bohle is obliged to undergo the certification process in order to ensure preventive protection in explosive areas,” said Thorsten Wesselmann, Technical Manager.

Together with the Head of Quality Management, Martin Schembecker, the ATEX commissioner Volker Bähr attended training sessions
to ensure that the processes could be carried out in accordance with the directive.

In February 2017, L.B. Bohle Maschinen + Verfahren GmbH received the positive news about the acceptance of the quality assurance
in the production process from the certifier.

“The certificate is valid until the end of 2019 and proves once again, that the safety and satisfaction of the customer are paramount
to L.B. Bohle”, Wesselmann continues.

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Apr 20, 2017

Tablet Checker KA 280 Impresses in Mumbai

Latest generation presented at the PMEC

Ever since the 1980s, the control unit KA from L.B. Bohle has been used worldwide in pharmaceutical production.
In November 2016 the specialist machine builder from Ennigerloh presented the latest generation of the effective tablet sorting machine
at the Indian trade fair PMEC.

The economical control of the thickness of sugar-coated tablets or film tablets is usually a decisive criterion in pharmaceutical solids production.
The automatic checker KA by L.B. Bohle has set standards for decades: the thickness of sugar- or film-coated pills, capsules or tablets is controlled mechanically.
With the series of checkers, L.B. Bohle has been successful in the market segment of tablet sorting for more than 30 years.
Just like its predecessors, the new KA 280 impresses with its high precision and high throughput. Up to 1,000,000 tablets can be checked
per hour.

The tablet checking process:
First, the feeding hopper is filled with the tablets to be checked. From there, they are transported via a vibration system to rotating sorting
discs that are arranged in pairs. Three different groups of tablets are distinguished by the disc pairs:
• Too thick tablets are placed in a tray above the dispensing tray
• Too thin tablets are placed in a tray below the middle tray
• Accepted tablets located between the upper and middle trays are fed to the production area

The entire process as well as the adjustment of the thickness measurement is also controlled via a touch panel (HMI). The thickness measurement
can be set to a deviation of ± 0.1 mm.

In the design of the new KA 280, the Bohle developers focused on ergonomic and simple handling. In addition, the KA was designed to
be low-maintenance. 

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About us

Company data

Export content

> 75%

Number of employees

100-499

Foundation

1981

Target groups
  • Industrial goods
  • Pharmaceuticals
  • Consumer goods (non-food)

Company information as a PDF file