NETZSCH Vakumix GmbH

Grinding and Dispersing of Pharmaceuticals

The comminution or desagglomeration of active pharmaceutical ingredients (API) is called micronization and brings about several advantages. The increase of the particle surface caused by the comminution results in a considerably better dissolution rate and bioavailability of the agents and therefore the APIs act faster. Due to the increased bioavailability a lower amount of APIs is required which in turn leads to a more cost-efficient product with less risks and side effects for the patient.

Based on comprehensive experience with the production of GMP-compliant pharmaceutical products, all sizes of NETZSCH DeltaVita® machines ranging from small laboratory- to production-size machines excel by the following specific features:

• All product wetted parts are designed and manufactured according to the latest GMP standards
• Material, production and calibration certificates are supplied together with the machine
• Optional cleaning in place (CIP) and sterilization in place (SIP)
• All indirectly product-wetted surfaces are made of stainless steel
• Optional data recording and formulation management
• Operator management with password protection for different levels of security
• Laboratory mills can be used with variable grinding chamber sizes
• Various materials like NETZSCH-Ceram Z, stainless steel 316 or nylon grinding chamber designs are available
• Splash-proof machine stand
• Comprehensive testing and qualification documentation, FAT, IQ, OQ, process validation
• Production of GMP compliant machines in the USA
• Trainings and seminars

Investment Security Right from the Start!

Quality right into the detail

A real „Scaling-Up“ from laboratory up to production without compromises, by means of identical design and performance compared to the production machines.

This is the real important point when developing a product.

It is necessary to react quickly and precisely and at the same time to guarantee a high product quality, as between invention of products and introduction of products always little time is left. The production has to supply right in time and this without quality deviations.

Therefore, at NETZSCH Vakumix the laboratory mixer has a very high significance and we guarantee the scaleability of the process parameters to the production machines.

The Makro-Recorder developed by NETZSCH Vakumix offers further advantages. The Makro-Recorder enables to record all manual recipe steps and procedures and to issue an automatic batch programme.

There are many innovative advantages in competition for your business. Please, do not hesitate to contact us. Together, we will find a solution.
Laboratory Mixers in different sizes are available for your requirements and applications, in order to cover all fields of development and sample manufacturing.

Our scope of delivery

• Laboratory Mixer KappaVita Type HM 2
• Laboratory Mixer KappaVita Type HM 5
• Laboratory Mixer KappaVita Type HM 15
• Laboratory Mixer KappaVita Type HM 35

Remove micronized Gas and Air Pockets with the NETZSCH Vacuum De-Aerator

In the NETZSCH Vacuum De-Aerator, micronized gases are removed from fluids with a wide range of viscosities. By means of the VTR Principle (vacuum – thin-film – rotary process), it is possible to process products from offset ink and shampoo, for example, to a wide variety of free-flowing compounds. The throughput is product and viscosity dependent and can range from 500 to 4000 kg/h. This machine can be used to de-gas both small quantities, from interchangeable tanks in batch operation, and large batches in continuous operation.